D-3263
CAS No. : 947257-66-1
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| Cat. No. : | HY-16162 |
| M.Wt: | 373.49 |
| Formula: | C21H31N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. In Vitro: D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1]. In Vivo: D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].
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