MT-7
CAS No. : 946507-08-0
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| Cat. No. : | HY-122249 |
| M.Wt: | 355.39 |
| Formula: | C22H17N3O2 |
| Purity: | >98 % |
| Solubility: |
MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules[1].
In Vitro:MT-7 (0-8µM; 72 h) inhibits cell proliferation with IC50 values ranging from 0.85 μM to 5.01 μM for HeLa, HL60, A549,MDA-MB-468, Lovo, HCT116, SMMC-7721, HO-8910, A375 and SG7901 cells[1].
MT-7 (5 μM; 12 h) induces cell cycle arrest at the G2/M phase[1].
MT-7 (5 μM; 1.5, 3, 6, 12 h) increases the gene expression of THBS, IL6 and PHLDA1, dereases the gene expression of COX5B, RPS11 and CYP26A1[1].
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