RN-1734
CAS No. : 946387-07-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $52 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $266 | In-stock |
| 100mg | $415 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19975 |
| M.Wt: | 353.31 |
| Formula: | C14H22Cl2N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM)[1]. RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells[2].
IC50 & Target: IC50: 2.3 μM (hTRPV4), 5.9 μM (mTRPV4), 3.2 μM (rTRPV4)[1]
In Vitro: RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis[2].
RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP[2].
In Vivo: RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse[2].
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