Remetinostat
CAS No. : 946150-57-8
(Synonyms: SHP-141)
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $135 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100365 |
| M.Wt: | 323.34 |
| Formula: | C16H21NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
Remetinostat (SHP-141) is a hydroxamic acid-based histone deacetylase (HDAC) inhibitor. Remetinostat alleviates Imiquimod (HY-B0180)-induced psoriatic dermatitis. Remetinostat can be used for study of cutaneous T-cell lymphoma[1][2]. IC50 & Target:HDAC[1]. In Vitro:Remetinostat (1-10 μM; 24 h) inhibits the expression of costimulatory molecules CD40 and CD86 on bone marrow-derived dendritic cells (BMDCs) stimulated by LPS (HY-D1056A1)[2]. In Vivo:Remetinostat (1% cream; topical application; once a day; 5 consecutive days) alleviates Imiquimod (HY-B0180)-induced psoriatic dermatitis in mice[2].
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