MPT0B002
CAS No. : 946077-08-3
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| Cat. No. : | HY-122151 |
| M.Wt: | 325.36 |
| Formula: | C19H19NO4 |
| Purity: | >98 % |
| Solubility: |
MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase[1].
In Vitro:MPT0B002 (1-1000 nM; 48 h) induces G2/M-phase cell cycle arrest[1].
MPT0B002 (100 nM; 24 h) inhibits cell viability in a dose-dependent manner in K562, BaF3/p210, and BaF3/T315I cells[1].
MPT0B002 (100 nM; 48 h) induces apoptosis and can downregulate both Bcr-Abl and Bcr-Abl-T315I mRNA expressions and protein levels and the downstream signaling pathways[1].
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