Isavuconazonium (sulfate)
CAS No. : 946075-13-4
(Synonyms: BAL8557-002)
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $520 | In-stock |
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| Cat. No. : | HY-100373 |
| M.Wt: | 814.84 |
| Formula: | C35H36F2N8O9S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 0.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis[1][2][3][4][5].
In Vitro:Isavuconazonium sulfate (0.006 nM-50 μM) inhibits trophoblast activity of three T4-genotype strains of Acanthamoeba (Ma, CDC:V240 and MEEI 0184) with EC50 vaules of 0.001 μM, 0.037 μM and 0.024 μM, respectively. And (100-200 μM; 48 h) has vesicle-extinguishing activity in three tested strains Ma, CDC:V240, and MEEI 0184 with mean minimum vesicle extinguishing concentration (MCC) of 167.1 μM, 136.0 μM, and 187.5 μM, respectively[2].
Isavuconazonium sulfate inhibits bacteria with minimum inhibitory concentration (MIC) < 0.015 μg/mL[5].
In Vivo:Isavuconazonium sulfate (215 mg/kg; p.o.; Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4].
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