LX-1031
CAS No. : 945976-76-1
| Size | Price | Stock |
|---|---|---|
| 2mg | $90 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $760 | In-stock |
| 100mg | $1200 | In-stock |
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| Cat. No. : | HY-13041 |
| M.Wt: | 538.52 |
| Formula: | C28H25F3N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. In Vivo: With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, the effects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice[1]. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum, jejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay[2].
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