TM6008
CAS No. : 945008-17-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-112678 |
| M.Wt: | 387.39 |
| Formula: | C21H17N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1]. In Vivo:TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat[1]. TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia[1].
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