Propargyl-PEG2-amine
CAS No. : 944561-44-8
| Size | Price | Stock |
|---|---|---|
| 1g | $22 | In-stock |
| 5g | $38 | In-stock |
| 10g | $73 | In-stock |
| 25g | $175 | In-stock |
| 100g | $578 | In-stock |
| 500g | $2888 | In-stock |
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| Cat. No. : | HY-W051634 |
| M.Wt: | 143.18 |
| Formula: | C7H13NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2]. Propargyl-PEG2-amine is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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