Murepavadin
CAS No. : 944252-63-5
(Synonyms: POL7080)
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| Cat. No. : | HY-P1674 |
| M.Wt: | 1553.81 |
| Formula: | C73H112N22O16 |
| Purity: | >98 % |
| Solubility: | H2O |
Murepavadin (POL7080), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with both MIC50 and MIC90 values of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance[1][2].
IC50 & Target:MIC50: 0.12 mg/L(P. aeruginosa)[2]
MIC90: 0.12 mg/L(P. aeruginosa)[2]
IC50: 5.84 μM (gentamicin)[2]
In Vitro: Murepavadin has activity against P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L[2].
Murepavadin inhibits megalin-mediated uptake of gentamicin in vitro with an IC50 value of 5.84 μM[2].
In Vivo: Murepavadin (s.c.; 0-100 mg/kg) is active in pre-clinical animal models including infections with XDR isolates[2].
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