SMER18
CAS No. : 944153-47-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 50mg | $1800 | In-stock |
| 100mg | $2520 | In-stock |
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| Cat. No. : | HY-18672 |
| M.Wt: | 287.74 |
| Formula: | C16H14ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. Target: mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
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