Peficitinib
CAS No. : 944118-01-8
(Synonyms: ASP015K; JNJ-54781532)
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $130 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $610 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-19568 |
| M.Wt: | 326.39 |
| Formula: | C18H22N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 60 mg/mL |
Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1].
IC50 & Target: IC50: 3.9 nM (JAK1), 5.0 nM (JAK2), 0.7 nM (JAK3), 4.8 nM (Tyk2)[1]
In Vitro: Peficitinib hydrobromide (0-100 nM; 3 days) inhibits IL-2-induced T cell proliferation in a concentration-dependent manner[1].
Peficitinib hydrobromide (10-1000 nM) inhibits IL-2-induced STAT5 phosphorylation in a concentration-dependent manner with a mean IC50 of 124 nM in rat whole blood, and inhibits STAT5 phosphorylation with a mean IC50 of 127 nM in human lymphocytes[1].
In Vivo: Peficitinib hydrobromide (1-30 mg/kg; p.o.; once daily for 24 days) shows dose-dependent efficacy both in prophylactic and therapeutic dosing regimens in an adjuvant-induced arthritis rat model[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Peficitinib
- Cat. No.:
- HY-19568
- Quantity:
Your information is safe with us.