BMS-303141
CAS No. : 943962-47-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $78 | In-stock |
| 10mg | $102 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $500 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16107 |
| M.Wt: | 424.30 |
| Formula: | C19H15Cl2NO4S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. IC50 & Target: IC50: 0.13 uM (ACL)[1] In Vitro: In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity[1]. In Vivo: Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h[1].
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