PI-828
CAS No. : 942289-87-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $575 | In-stock |
| 50mg | $825 | In-stock |
| 100mg | $1130 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108606 |
| M.Wt: | 322.36 |
| Formula: | C19H18N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 12.5 mg/mL |
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1].
In Vitro: PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells[2].
PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[3].
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