Ruxolitinib (Standard)
CAS No. : 941678-49-5
(Synonyms: INCB18424 (Standard))
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| Cat. No. : | HY-50856R |
| M.Wt: | 306.37 |
| Formula: | C17H18N6 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble); DMSO : ≥ 100 mg/mL (326.40 mM) |
Ruxolitinib (Standard) is the analytical standard of Ruxolitinib. This product is intended for research and analytical applications. Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3]. IC50 & Target:IC50: 3.3 nM (JAK1), 2.8 nM (JAK2)
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