PKM2-IN-1
CAS No. : 94164-88-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $245 | In-stock |
| 100mg | $320 | In-stock |
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| Cat. No. : | HY-103617 |
| M.Wt: | 345.48 |
| Formula: | C18H19NO2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM[1]. IC50 & Target:IC50: 2.95 μM (PKM2)[1] In Vitro: PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively[1].
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