Cerebellin

Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research^[1][2][3][4]. In Vitro:Cerebellin (1-100 nM; 10-30 min) potently stimulates the production of norepinephrine and cyclic adenosine monophosphate in rat adrenal medullary tissues via an adenylate cyclase/PKA-dependent pathway^[1].
Cerebellin (1-100 nM; 90 min) inhibits glucose-stimulated insulin secretion from isolated rat islets^[2].
Cerebellin (100 nM-1 μM; 1 hour) inhibits glucose/Exendin-4 (HY-13443)-stimulated insulin secretion in INS-1 cells^[2].
Cerebellin (10 nM-1 μM; 5 min) reduces Forskolin (HY-15371)-induced cAMP accumulation in INS-1 cells in a concentration-dependent manner^[2].
Cerebellin (100 nM) irreversibly reduces the intracellular free calcium concentration in INS-1 cells^[2]. In Vivo:Cerebellin (1-1000 nM; intrarenal adrenal perfusion; continuous administration during sample collection) potently stimulates norepinephrine release from perfused rat adrenal glands via an adenylate cyclase/PKA-dependent pathway^[1].
Cerebellin (0.5-1.5 nmol/100 g body weight; subcutaneous injection; single bolus) acts as an insulin inhibitor in healthy female Wistar rats^[2].