Suplatast (Tosilate)
CAS No. : 94055-76-2
(Synonyms: IPD 1151T)
| Size | Price | Stock |
|---|---|---|
| 50mg | $25 | In-stock |
| 100mg | $46 | In-stock |
| 250mg | $99 | In-stock |
| 500mg | $164 | In-stock |
| 1g | $273 | In-stock |
| 5g | $800 | In-stock |
| 10g | $1120 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-17002 |
| M.Wt: | 499.64 |
| Formula: | C23H33NO7S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL;H2O : ≥ 100 mg/mL |
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity[1][2][3][4].
In Vitro: IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis[1].
IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC)[1].
In Vivo: Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma[2].
Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum[3].
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