MCPA

MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds^{[1][2][3][4][5]}. In Vitro:MCPA (50 μM) is taken up by Caco-2 cells mainly via monocarboxylic acid transporters shared with benzoic acid and partially via L-lactic acid^[1].
MCPA (20-120 μM; 4 weeks) inhibits growth of non-green potato tuber calli, disrupts membrane integrity, reduces energy charge, and affects redox state and antioxidant enzyme activities^[2].
In Vivo:MCPA (200 mg/kg/day; p.o.; 2 weeks) increases hepatic cytochrome P-450 level and activities of aniline hydroxylase and 7-ethoxycoumarin O-deethylase in male rats^[4].
MCPA (¹⁴C-MCPA; 5-100 mg/kg; p.o.; single or multiple doses) is rapidly absorbed and excreted mainly in urine in rats, with limited metabolism to HMCPA and glycine conjugate^[5].