Piperonylic acid


CAS No. : 94-53-1

(Synonyms: 2H-1,3-benzodioxole-5-carboxylic acid)

94-53-1
Price and Availability of CAS No. : 94-53-1
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Cat. No. : HY-41404
M.Wt: 166.13
Formula: C8H6O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 94-53-1 :

Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities[1][2][3][4]. In Vitro:Piperonylic acid (10 mg/mL, 24 h) has inhibitory effects on both gram-negative and gram-positive bacteria, of which S. epidermidis is the most sensitive with the MIC value is 78.12 mg/ml[3].
Piperonylic acid (50/100 μM, 24 h) ultimately promotes the growth and survival of HaCaT cells and restores cell viability after UV-induced cell damage by activating the EGFR signaling pathway[2].
Piperonylic acid (20-300 μg/mL, 60 min) has antioxidant activity and inhibits the oxidation of β-Carotene (HY-N0411) [3].
In Vivo:Piperonylic acid (20 μL of 10 μM per day, applied topically to wounds) accelerates wound healing in mice by modulating inflammation and collagen deposition[4].

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