Chlorpropamide
CAS No. : 94-20-2
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| Cat. No. : | HY-B1429 |
| M.Wt: | 276.74 |
| Formula: | C10H13ClN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 0.67 mg/mL (ultrasonic) |
Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone[1][2][3][4].
In Vitro:Chlorpropamide (0.1 mM, 90 min) increases the cAMP accumulation in the thick ascending limb of the loop of Henle (MAL)[1].
In Vivo:Chlorpropamide (2 mg/kg; subcutaneously; once daily; seven days) enhances the antidiuretic effect of vasopressin (VP) by increasing the tension in the medullary and papillary regions of rats[1].
Chlorpropamide (20-200 mg/kg; subcutaneously; once daily; three months) does not significantly affect the structure or function of pancreatic islets in diabetic rats[2].
Chlorpropamide (250 mg/kg; orally; single dose) lowers blood sugar levels in rats[3].
Chlorpropamide (2.5-250 mg/kg; orally; single dose) can affect the metabolism of acetaldehyde in mice, and this is related to the mouse strain[4].
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