Propylparaben
CAS No. : 94-13-3
(Synonyms: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate)
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| Cat. No. : | HY-N2026 |
| M.Wt: | 180.20 |
| Formula: | C10H12O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury[1][2][3][4][5].
In Vitro:Propylparaben shows weak estrogenic activity, with a potency approximately 30,000-fold less than 17β-estradiol[1].
Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways[5].
In Vivo:Propylparaben (0-1% in diet; dietary; continuous; 28 days) disrupts male reproductive function in immature rats, causing dose-dependent reductions in sperm parameters and serum testosterone[1].
Propylparaben (7.5 mg/kg; p.o.; daily for 8 months) significantly alters the estrous cycle, hormone levels and ovarian reserve, and accelerated ovarian aging in mice[6].
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