CCI-007
CAS No. : 939228-52-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $740 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122698 |
| M.Wt: | 336.36 |
| Formula: | C15H16N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1].
In Vitro: CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia[1].
Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2[1].
Resistance to CCI-007 can occur by upregulation of MLL target gene expression[1].
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