| Size | Price | Stock |
|---|---|---|
| 500μg | $418 | Get quote |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-19825 |
| M.Wt: | 570.38 |
| Formula: | C27H21Cl2N3O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2].
In Vitro: Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) [1].
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis[3].
In Vivo: Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].
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