Rebeccamycin


CAS No. : 93908-02-2

93908-02-2
Price and Availability of CAS No. : 93908-02-2
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Cat. No. : HY-19825
M.Wt: 570.38
Formula: C27H21Cl2N3O7
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 93908-02-2 :

Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II[1][2]. In Vitro: Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) [1].
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis[3]. In Vivo: Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia[2].

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