8-CPT-Cyclic AMP (sodium)
CAS No. : 93882-12-3
(Synonyms: 8-CPT-cAMP (sodium); 8-(p-Chlorophenylthio)-cAMP (sodium))
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $285 | In-stock |
| 100mg | $450 | In-stock |
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| Cat. No. : | HY-111673 |
| M.Wt: | 493.79 |
| Formula: | C16H14ClN5NaO6PS |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC50Epac and is a potent Epac activator[1][2]. In Vitro: a-Fas and TNF-α/CHX induces neutrophil death rapidly (within 2 h) to at least 90%. The commonly used cAMP analog 8-pCPT-cAMP (0.7 mM) delays TNF- /CHX-induced and a-Fas-induced apoptosis. It is more efficient against apoptosis induced by TNF- /CHX than against a-Fas[2].
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