ATPγS (tetralithium salt)
CAS No. : 93839-89-5
(Synonyms: Adenosine-5'-O-(3-thiotriphosphate) (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate (tetralithium salt))
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| 10mg | $338 | In-stock |
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| Cat. No. : | HY-108666 |
| M.Wt: | 546.98 |
| Formula: | C10H12Li4N5O12P3S |
| Purity: | >98 % |
| Solubility: | H2O : 75 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis[1][2][3][4][5].
In Vitro:ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1].
ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].
In Vivo:ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3].
ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].
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