CAY10526
CAS No. : 938069-71-7
| Size | Price | Stock |
|---|---|---|
| 25mg | $125 | In-stock |
| 50mg | $188 | In-stock |
| 100mg | $282 | In-stock |
| 250mg | $423 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-118119 |
| M.Wt: | 311.16 |
| Formula: | C12H7BrO3S |
| Purity: | >98 % |
| Solubility: | DMSO : 66.67 mg/mL (ultrasonic;warming;heat to 60°C) |
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1].
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