6-(Dimethylamino)purine

6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis)^[1][3][5].
IC50 & Target:protein kinase^[1]. In Vitro: 6-(Dimethylamino) purine (2.5 mM. 3 h) accelerates the transition to interphase in activated mouse oocytes by inhibiting protein kinases^[1].
6-(Dimethylamino) purine blocks DNA synthesis in activated mammalian oocytes^[2].
6-(Dimethylamino) purine inhibits prolactin induced expression of milk protein genes in rabbit mammary gland cells^[3].
6-(Dimethylamino) purine (0.5 mM, 6 h) affects sperm motility and vitality in mammals and insects by regulating protein phosphorylation non phosphorylation changes^[4].
6-(Dimethylamino) purine (5 mM, 16 h) induces apoptosis in lymphoma cells by inhibiting protein kinases, leading to a significant downregulation of all genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-derived gene 1, and serine protease inhibitor 2 genes^[5].