Difamilast
CAS No. : 937782-05-3
(Synonyms: OPA-15406)
| Size | Price | Stock |
|---|---|---|
| 5mg | $185 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $825 | In-stock |
| 100mg | $1237 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-109085 |
| M.Wt: | 446.44 |
| Formula: | C23H24F2N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD)[1][2][3]. In Vitro:OPA-15406 is highly selective for inhibition of PDE4 subtype B (IC50=11.2 nM), and OPA-15406 also exerts inhibitory effects on PDE2[2]. In Vivo:OPA-1540 improves skin condition in relevant animal models of AD[1].
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