QM31
CAS No. : 937735-00-7
(Synonyms: SVT016426)
| Size | Price | Stock |
|---|---|---|
| 5mg | $580 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $1900 | In-stock |
| 50mg | $3200 | In-stock |
| 100mg | $5000 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125018 |
| M.Wt: | 768.56 |
| Formula: | C39H38Cl4N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2]. In Vitro: SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM in HeLa S100 cells[3].
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