Hydroxy-PEG4-acid
CAS No. : 937188-59-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $27 | In-stock |
| 250mg | $44 | In-stock |
| 1g | $105 | In-stock |
| 5g | $309 | In-stock |
| 10g | $548 | In-stock |
| 25g | $1096 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-117104 |
| M.Wt: | 266.29 |
| Formula: | C11H22O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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