Pimelic Diphenylamide 106
CAS No. : 937039-45-7
(Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $240 | In-stock |
| 100mg | $360 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19348 |
| M.Wt: | 339.43 |
| Formula: | C20H25N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
Pimelic Diphenylamide 106 (TC-H 106) is a slow, tight binding class I HDAC inhibitor (inhibits HDAC1, 2, and 3 with IC50 values of 150 nM, 760 nM, and 370 nM, respectively), with no activity against class II HDACs. Pimelic Diphenylamide 106 modulates dopamine concentration and protects dopamine cells by inducing VMAT2 expression. Pimelic Diphenylamide 106 can be used in the study of neuropsychiatric diseases such as attention deficit hyperactivity disorder (ADHD)[1][2][3]. In Vitro:Pimelic Diphenylamide 106 (0-10 µM; 24 h) reduces the damage and cell death of SH-SY5Y cells induced by 6-OHDA (500 µM)[3]. In Vivo:Pimelic Diphenylamide 106 (50 mg/kg, i.p.; once daily for 3 days) reduces hyperactivity in cognitively impaired young mice[3]。
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