TPN729
CAS No. : 936951-20-1
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| Cat. No. : | HY-116808 |
| M.Wt: | 516.66 |
| Formula: | C25H36N6O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction[1]. In Vivo:TPN729 (1.25, 2.5 and 5.0 mg/kg; intraduodenal injection, once) increases intracavernous pressure/blood pressure (ICP/BP) with the dose of 5.0 mg/kg at all time points and with the dose of 2.5 mg/kg at 75, 90, 105, and 120 minutes time points[1]. TPN729 (5.0 μg/kg; i.v., once) significantly increases ICP and ICP/BP of male Beagle dogs[1].
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