Sacubitril/Valsartan
CAS No. : 936623-90-4
(Synonyms: LCZ696)
| Size | Price | Stock |
|---|---|---|
| 5mg | $77 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $209 | In-stock |
| 100mg | $295 | In-stock |
| 500mg | $590 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-18204A |
| M.Wt: | 957.99 |
| Formula: | C48H55N6Na3O8.2.5H2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : ≥ 50 mg/mL |
Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure[1][2][3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis[4].
IC50 & Target:Angiotensin receptor-neprilysin[1]
In Vitro: Sacubitril/Valsartan (LCZ696; 1-30 μM; 0.5?hours) inhibits HG-treated H9C2 cells apoptosis in an experimental model of Diabetic cardiomyopathy (DCM)[4].
Sacubitril/Valsartan (1-30 μM; 0.5?hours) increases the expression level of cleaved caspase-3 and the ratio of Bax/Bcl-2 in HG-treated H9C2 cells[4].
In Vivo: Sacubitril/Valsartan (LCZ696; perorally; 68 mg/kg for 4 weeks) significantly exhibits small weights and reduces interstitial fibrosis both in the noninfarct zone and peri-infarct zone[2].
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