Ceftolozane (sulfate)
CAS No. : 936111-69-2
(Synonyms: CXA-101; FR264205)
| Size | Price | Stock |
|---|---|---|
| 1mg | $552 | In-stock |
| 5mg | $1380 | In-stock |
| 10mg | $2340 | In-stock |
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| Cat. No. : | HY-19806A |
| M.Wt: | 764.77 |
| Formula: | C23H32N12O12S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;heat to 60°C);H2O : 10 mg/mL (ultrasonic) |
Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. Ceftolozane binds to P. aeruginosa essential PBPs (1b, 1c, 2 and 3) with high affinity. Ceftolozane inhibits cell wall synthesis by binding the PBPs. Ceftolozane sulfate inhibits P. aeruginosa and Enterobacteriaceae[1][2][3][4][5][6][7].
IC50 & Target:MIC: 0.5 μg/mL (P. aeruginosa PAO1)[1]
In Vitro:Ceftolozane sulfate shows antibacterial activity against fully AmpC-derepressed P. aeruginosa, with MIC of 4 mg/L[4].
Ceftolozane sulfate (≤0.12->64 μg/mL) shows antipseudomonal activity, including against carbapenem-resistant and MDR isolates, with MICs of >8 μg/mL for 11 carbapenem-resistant P. aeruginosa isolates (4.7%)[5].
In Vivo:Ceftolozane (400-800 mg/kg, s.c., every 6 h) sulfate reduces ESBL-producing Enterobacteriaceae in neutropenic mice[6].
Ceftolozane (180 mg/kg, s.c., every 8 h, 48 h) sulfate reduces bacterial load and improves early pulmonary inflammatory response without impairing 48 h post-infection homeostasis in a mice model of Pseudomonas aeruginosa acute pneumonia[7].
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