UBP316
CAS No. : 936095-50-0
(Synonyms: ACET)
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $390 | In-stock |
| 50mg | $1360 | In-stock |
| 100mg | $2180 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107601 |
| M.Wt: | 429.45 |
| Formula: | C20H19N3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C);1M NaOH : 80 mg/mL (ultrasonic;adjust pH to 11 with NaOH) |
UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a Kb value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist[1].
IC50 & Target: Kb: 1.4 nM (GluK1)[1]
In Vitro: UBP316 is ineffective at GluK2 (GluR6) receptors at all concentrations tested (up to 100 μM) and had no effect at GluK3 (GluR7) when tested at 1 μM[1].
UBP316 (200 nM) reduces short-term facilitation of pre-synaptic calcium transients following repetitive spikes[1].
UBP316 effectively antagonises GluK1-mediated depression of excitatory transmission in CA1 region of the hippocampus in vitro[1].
UBP316 blocks induction of NMDA receptor-independent long-term potentiation (LTP)[1].
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