Sp-cAMPS (triethylamine)

Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC₅₀ of 40 μM^[1][2][3]. In Vitro: Treatment of hepatocytes with Sp-cAMPS triethylamine, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca²⁺ can be mimicked by Sp-cAMPS triethylamine^[4]. In Vivo: In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) triethylamine into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals^[5].