7-Methyladenine
CAS No. : 935-69-3
(Synonyms: N7-Methyladenine)
| Size | Price | Stock |
|---|---|---|
| 100mg | $79 | In-stock |
| 250mg | $120 | In-stock |
| 1g | $442 | In-stock |
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| Cat. No. : | HY-116496 |
| M.Wt: | 149.16 |
| Formula: | C6H7N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.56 mg/mL (ultrasonic;warming;adjust pH to 3 with 1M HCl;heat to 60°C) |
7-Methyladenine (N7-Methyladenine), a methylated analog of Adenine (HY-B0152), is a biomarker of DNA damage from exposure to methylating agents[1].
In Vitro:The higher acidity of 7-Methyladenine leads to its enzymatic cleavage from damaged DNA, and due their instability as nucleosides, it is therefore possible to isolate and determine these methyladenines as simple nucleobases[1].
In Vivo:The concentration of 7-Methyladenine is increased in the urine of rats exposed to methylating agents such as dimethylnitrosamine, N-nitroso-N-methylurea, methylnitronitrosoguanidine and dimethyl sulfate[1].
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