TAK-901
CAS No. : 934541-31-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $670 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12201 |
| M.Wt: | 504.64 |
| Formula: | C28H32N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 65 mg/mL (ultrasonic) |
TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively.
IC50 & Target:IC50: 21 nM (aurora A), 15 nM (aurora B), 1.2 nM (JAK3), 1.3 nM (Src), 2 nM (FGR), 5 nM (FLT3)[1]
In Vitro:TAK-901 exhibits time-dependent, tight-binding inhibition of Aurora B, but not Aurora A[1].
TAK-901 suppresses histone H3 phosphorylation in a dose-dependent manner with an EC50
value of 0.16 μM in PC3 cells[1].
TAK-901 is a substrate of the P-glycoprotein (PgP) drug efflux pump, as shown by the decrease in
EC50 from 38 nM in the uterine sarcoma MES-SA cells to more than 50 μM in drug-resistant MES-SA/Dx5 expressing high levels of PgP[1].
| Cell line | EC50 (μM) |
|---|---|
| A2780 | 0.085 |
| A375 | 0.39 |
| A498 | 0.2 |
| A549 | 0.13 |
| COLO205 | 0.11 |
| DLD1 | 1.5 |
| H226 | 0.11 |
| H358 | 0.077 |
| H460 | 0.81 |
| HT29 | 0.062 |
| MDA-MB-435S | 0.12 |
| MES-SA | 0.043 |
| MKN-45 | 0.16 |
| PC3 | 0.19 |
| IMR-90 | 0.088 |
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