TY-52156
CAS No. : 934369-14-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19736 |
| M.Wt: | 364.27 |
| Formula: | C18H19Cl2N3O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM[1].
IC50 & Target: Ki: 110 nM (S1P3)[1]
In Vitro: TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i[1].
TY-52156 shows submicromolar potency and a high degree of selectivity for S1P3 receptor[1].
TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation[1].
In Vivo: TY-52156 (10 mg/kg, 30 mg/kg; p.o.) suppresses S1P3 receptor-induced bradycardia after oral administration in vivo[1].
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