TBCA
CAS No. : 934358-00-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $483 | In-stock |
| 50mg | $724 | In-stock |
| 100mg | $1086 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110052 |
| M.Wt: | 463.74 |
| Formula: | C9H4Br4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
In Vitro: TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1].
TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1].
TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2].
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