AZD 2066
CAS No. : 934282-55-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $234 | In-stock |
| 5mg | $468 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-110255 |
| M.Wt: | 381.82 |
| Formula: | C19H16ClN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming) |
AZD-2066 is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 activates the BDNF/trkB signaling pathway. AZD 2066 can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease[1][2][3][5].
IC50 & Target:mGluR5[1]
In Vitro:AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2, 3.56, 96.2, and 380 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[4].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG (HY-12598A), and blocks either DHPG or Quis effects in mGlu5/HEK cells[4].
In Vivo:AZD 2066 (0.3-30 mg/kg, p.o., 60 min) shows discriminative effects in rats[2].
AZD-2066 (10 µM, perfusion of brain slide) alleviates dihydroxyphenylglycine (DHPG)-facilitated long-term depression (LTD) expression in chronic social defeat stress (CSDS)-treated mice via BDNF/trkB signaling pathway[5].
AZD-2066 (5 mg/kg, i.p., 2 × 12 h) alleviates chronic social defeat stress (CSDS)-induced depressive behaviors in mice[5].
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