Venlafaxine
CAS No. : 93413-69-5
(Synonyms: Wy 45030)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $86 | In-stock |
| 50mg | $131 | In-stock |
| 100mg | $210 | In-stock |
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| Cat. No. : | HY-B0196 |
| M.Wt: | 277.41 |
| Formula: | C17H27NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
In Vitro: Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM[1].
Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED50 values of 2 and 54 mg/kg, respectively[1].
In Vivo: Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA[1].
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