2-(Aminomethyl)phenol

2-(Aminomethyl)phenol (2-Hydroxybenzylamine) is a selective dicarbonyl scavenger. 2-(Aminomethyl)phenol is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can prevent early recurrence of atrial fibrillation. 2-(Aminomethyl)phenol can reduce inflammation and plaque apoptotic cells and promote efferocytosis and features of stable plaques. 2-(Aminomethyl)phenol can reduce malondialdehyde (MDA)-LDL and MDA-HDL levels in Ldlr^-/- mouse model. 2-(Aminomethyl)phenol can be studied in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias^[1][2]. In Vitro:2-(Aminomethyl)phenol (Compound 2-HOBA) (500 μM, 24 h) markedly decreases the number of apoptotic cells in both macrophage and human aortic endothelial cells^[2]. In Vivo:2-(Aminomethyl)phenol (Compound 2-HOBA) (1 g/L, p.o., 2 w pretreatment and 16 w afterwards) reduces the extent of proximal aortic atherosclerosis by approximately 31% in female Ldlr^-/- mouse model^[2].