PPQ-102
CAS No. : 931706-15-9
(Synonyms: CFTR Inhibitor)
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $168 | In-stock |
| 25mg | $357 | In-stock |
| 50mg | $606 | In-stock |
| 100mg | $1020 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14179 |
| M.Wt: | 438.48 |
| Formula: | C26H22N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1].
IC50 & Target: IC50: ~90 nM (CFTR)[1].
In Vitro: PPQ-102 (0, 0.5, 5μM, 4 days) prevents and reverses renal cyst expansion in an embryonic kidney organ culture model of PKD[1].
PPQ-102 (0, 0.5, 5μM, 3 days) shows ability of reducing fluid accumulation in preformed cysts[1].
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