IOX2
CAS No. : 931398-72-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $119 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $462 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15468 |
| M.Wt: | 352.34 |
| Formula: | C19H16N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases[1][2].
IC50 & Target:IC50: 22 nM (PHD2)[2]
In Vitro:IOX2 (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3[1].
IOX2 also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction[1].
IOX2 (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition[2].
In Vivo:IOX2 (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice[1].
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