R 59-022
CAS No. : 93076-89-2
(Synonyms: DKGI-I; Diacylglycerol kinase inhibitor I)
| Size | Price | Stock |
|---|---|---|
| 5mg | $89 | In-stock |
| 10mg | $157 | In-stock |
| 25mg | $362 | In-stock |
| 50mg | $615 | In-stock |
| 100mg | $984 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107613 |
| M.Wt: | 459.58 |
| Formula: | C27H26FN3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4].
In Vitro:R 59-022 (10 μM, 1 min) potentiates platelet aggregation[2].
R 59-022 (30 uM, 0-60 min) increases release of Noradrenaline in chromaffin cells[3].
R 59-022 (40 uM, 30 min) activates PKC in HeLa and U87 cells[4].
R 59-022 (0-10 uM, 4 h) blocks EBOV entry into Vero cells[5].
In Vivo:R 59-022 (2 mg/kg, i.p., 12 days) significantly increases median survival in SCID mice implanted with U87 GBM cells[6].
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