Creosol
CAS No. : 93-51-6
(Synonyms: 2-Methoxy-4-methylphenol)
| Size | Price | Stock |
|---|---|---|
| 25g | $17 | In-stock |
| 100g | $28 | In-stock |
| 500g | $70 | In-stock |
| 1000g | $116 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W040971 |
| M.Wt: | 138.17 |
| Formula: | C8H10O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable[1][2][3].
In Vitro:Creosol (50-500 μM, 72 h) is a uremic toxin that induces cellular senescence, thereby leading to impaired function of mesenchymal stem cells (MSCs) through FAK-Akt-TWIST signaling pathway[4].
Creosol is a neurotoxin at high concentration, and alters the neurometabolism at low concentration. Creosol (1 µM, 5 days) promotes the neural differentiation and BDNF secretion in cell PC-12[5].
Creosol (0-20 µM, 15 min) inhibits ROS generation and ERK/p38 signaling pathway, blocking thereby the Arachidonic acid (HY-109590)-induced platelet aggregation[7].
In Vivo:Creosol (50 mg/kg, po for 4 weeks) alters the composition of the intestinal microbiota, and induces autistic-like behaviors in mouse models[6].
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