Skimmin

Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases^[1][2][3][4]. In Vitro:Skimmin (2-10 μM, 48 h) alleviates the increase of NLRP3, caspase-1, and IL-1 in primary cardiomyocytes from SD rats^[3]. In Vivo:Skimmin (15-30 mg/kg, i.g., daily from days 37 to 66) decreases average albuminuria level by 13.5% (15 mg/kg dose) and 36.0% (30 mg/kg dose) in female SD rats^[1].
Skimmin (15-30 mg/kg, i.g., 16 w) showed a certain effect on decreasing blood glucose in male SD rats^[3].
Skimmin (7.5-30 mg/kg, p.o., 17 w) results in significantly less severe sclerosis in glomerulus segments especially at 15 mg/kg and 30 mg/kg dose in Wistar rats^[4].