Guaifenesin
CAS No. : 93-14-1
(Synonyms: Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate)
| Size | Price | Stock |
|---|---|---|
| 100g | $29 | In-stock |
| 500g | $112 | In-stock |
| 1000g | $209 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-B0264 |
| M.Wt: | 198.22 |
| Formula: | C10H14O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming) |
Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough[1][2].
In Vitro:Guaifenesin (2 or 20 µg/mL, 6-48 h) inhibits mucin release in epithelial cultures[3].
Guaifenesin (10-300 μM, 3-24 h) inhibits IL-13-induced MUC5AC content and secretion in primary human airway epithelial cells[4].
In Vivo:Guaifenesin (50 mg/kg, p.o.; or 10 mg/kg, i.v.; rats) shows a t1/2 of 45.6 h (p.o.), and 49.0 h (i.v.), AUC of 2469 (p.o.) and 711 (i.v.) μg·min/mL[5].
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